The 2018 China Intestinal Congress officially kicked off at 8 am on May 12 at the National Convention Center in Beijing. At the opening ceremony, Prof. Gao Fu from the Chinese Center for Disease Control and Prevention; Prof. Fan Daiming from Xijing Hospital of Gastroenterology, Air Force Medical University; Prof. Yin Yulong from Institute of Subtropical Agriculture, Chinese Academy of Sciences; Prof. Wei Fuwen from Institute of Zoology, Chinese Academy of Sciences; Prof. Zhao Liping from Rutgers University and Shanghai Jiao Tong University; and Prof. Dusko from the French National Institute of Agricultural Research Professor Ehrlich and Professor Wu Kaichun of Xijing Gastroenterology Hospital of Air Force Medical University made excellent presentations respectively.
In his opening speech, Academician Gao Fu stressed the importance of promoting disease prevention and control in China, advocating that disease prevention and control should be shifted to promoting health awareness. Although health is closely related to the gut, we should not simply link all diseases to the gut flora. Instead, we should pay more attention to the combination of the human body and the microbes.
In his speech, Academician Fan Daiming first introduced the emerging concept of integrative medicine, reviewed the status of the founding meeting of the Chinese Integrative Medicine Alliance, and announced the establishment of the Chinese Integrative Medicine and Microecology Alliance on the day of the meeting, aiming at focusing on microbiology and human health. "Reverse medical research" was then discussed. Academician Fan Daming believes that the current medical science blindly develops towards technology and micro. Because the human body is too complex, such research methods are too partial and one-sided, so the research results are usually of little significance for clinical guidance. In contrast, "reverse medicine" advocates results-oriented research, that is, mechanism research tracing upstream after achieving clinical results. And suggested that "old drugs should be used in new", multi-disciplinary, multi-system integration of drug use.
Professor Liping Zhao brings with him a blockbuster study recently published in Science by his team and collaborators. After intervention with a high dietary fiber diet in patients with type 2 diabetes, all disease indicators were alleviated. In addition, the high-fiber diet enriched 15 strains that produced acetic or butyric acid in patients. The 15 strains enriched by high dietary fiber can be used as a complete functional group to improve insulin level and blood glucose control in diabetic patients. This study provides a new idea for the prevention and treatment of diabetes from the perspective of intestinal flora intervention.
In his special report, Academician Yin Yulong introduced his team's latest research progress on intestinal development and the regulation of weaning stress damage repair in piglets. In the total production value of our country's animal husbandry, raising pigs takes up more than half. However, it is worth noting that the mortality rate of piglets accounts for 50-70% of the total mortality rate in the pig breeding industry, resulting in an annual economic loss of nearly 30 billion yuan. However, intestinal health problems are exactly one of the major factors restricting pig breeding in China. In addition, because of the similarity of structure and metabolism, the intestinal tract of piglets can be used as a model for human infant intestinal tract research. The team of Academician Yin Yulong conducted a detailed study on intestinal mucosal morphology, skin proliferation, oxidative stress of barrier function and intestinal microflora composition of piglets, and explained how weaning stress affects intestinal microflora, development and metabolism of piglets. At the same time, the health status of piglets can be improved significantly by regulating the intestinal environment of piglets through nutritional intervention.
Academician Wei Fuwen's research on the intestinal flora of "national treasure" giant panda has attracted great attention. In the study, Wei's team found that wild giant pandas have similar flora structure, but during food changes, such as from bamboo leaf and bamboo shoot stage to conversion stage, the intestinal microbial function of giant pandas is significantly different. Next, his research group selected different bear feces for analysis, and found that they had similar structures and functions, which could adapt to high-purine food and resist obesity diet. Through this series of studies, we can explore new conservation policies for captive pandas.
In his report, Prof. Dusko Ehrlich cautions that although it is now possible to quantify changes in the microbiota in different diseases through sequencing technology, changes in the microbiota can be used as biomarkers in diagnosis and treatment. However, it is important to establish the criteria for the identification of flora, and there is an urgent need to establish disease-related flora models. In addition, the importance of individual strains and the whole bacterial community to human health should not be ignored, and some strains with a small total amount may also play an important role.
In the final speech of the opening ceremony, Professor Wu Kaichun introduced the present situation and development trend of clinical trials of perococcus group transplantation. The imbalance of intestinal microecology is closely related to human health, and probiotics, antibiotics, dietary intervention and fecal bacteria transplantation are four main ways to improve intestinal microecology. Currently, 218 clinical trials of fecal bacteria transplantation have been registered worldwide, most of which are for digestive tract diseases. In addition, there are a few applications in neurological, tumor, infection and other diseases. Fecal bacteria transplantation methods include fresh fecal bacteria, freeze-dried fecal bacteria, capsules. Overall, clinical response rates for fecal transplants were similar compared to biologics. However, in the actual clinical treatment, attention should be paid to the selection of the donor and the safety of the experiment.
The 2018 China Intestinal Conference is a large-scale interdisciplinary and cross-professional academic exchange platform jointly initiated and founded by Professor Zhang Invention of the Second Affiliated Hospital of Nanjing Medical University and LAN Canhui of Warm-hearted Biotechnology Research Institute. It was co-organized by Professor Nie Yongzhan, Hospital of Gastroenterology, Air Force Military Medical University; Professor Zhu Baoli, Institute of Microbiology, Chinese Academy of Sciences; Professor Wei Hong, School of Basic Medical Sciences, Army Military Medical University; Professor Zhao Fangqing, Beijing Institute of Life Sciences, Chinese Academy of Sciences; Professor Wang Jun, Institute of Microbiology, Chinese Academy of Sciences; and Dr. Zhang Xiaoxue, Journal of Protein and Cell. The conference consists of four sessions: China Integrated Enterology Conference (China Microbiome Transplantation Conference), China Human Microbiome Conference, China Animal Gut Conference, Protein and Cell special journal academic, and Chinese Journal of Microbiology paper soliciting exchange, "Intestinal", "Business" speech and other activities. There will be more than 2,000 participants, and nearly 100 experts from home and abroad, including 4 academicians of Chinese Academy of Sciences/Chinese Academy of Engineering, will give keynote presentations at the conference.
In addition to the academic aspects, this China Intestinal Conference also contains many highlights: the conference is organized in the form of collaborative crowdsourcing, and each sub-conference is held by different organizers; The "Gut • Tao" lecture takes the form of TED talk, presenting an academic feast with excellent audio-visual experience for the audience. In addition, during the report period, the academicians and experts awarded G30 enterprise certificates to 11 enterprises, the first members of the G30 project of Warm-hearted Technology Research Institute.
