Zhao Mengyao
The 2018 China Intestinal Congress will be held at the National Convention Center in Beijing from May 11 to 13. The Grand Feast of Intestinal Science and Technology will be held with the full coverage of 4 international academic conferences, led by 5 academicians of the Chinese Academy of Sciences and the Chinese Academy of Sciences, over 100 authoritative experts, the participation of 7 countries and regions, 8 "Intestinal · Daoism" lectures, and the release of 60+ annual scientific and technological innovations. This interdisciplinary conference is in line with the needs of The Times. It focuses on the fields of intestinal flora, complex intestinal diseases, new technologies for intestinal diagnosis and treatment, severe infections, new technologies for entero-anal endoscopic intervention, micro-ecological combined immunotherapy for metabolic diseases and tumors, innovative drug device research and development, nutrition, model animals, animal intestinal health, food science and other fields. It will focus on reporting the latest global developments and continuing education for professional and technical personnel.
China Intestinal Congress website
In recent years, basic intestinal research, especially intestinal flora research, has become the star of attention. Whether it is the Human Microbiome Project (HMP) initiated and completed by NIH, And the EU-led Metagenomics of the Human Intestinal Tract (metaHIT), The relaunch of the US $521 million National Microbiome Initiative (NMI) in 2016, as well as numerous studies of gut microbiota by microbiologists around the world, demonstrate the high level of enthusiasm for gut microbiota research around the world.
In fact, the functions of gut microbes, such as helping digest food or causing digestive diseases such as abdominal pain and diarrhea, have been poorly understood. With the in-depth research and the development of metagenomic sequencing and other technologies, researchers have found that intestinal microbes play an extremely important role in nutrient metabolism, human development, immune and other organ diseases, and even chronic diseases such as diabetes and obesity. They even affect the therapeutic effect of cancer.
For example, researchers have found that the efficacy of anti-PD-1 monoclonal antibody against melanoma, lung cancer, kidney cancer and other tumors is surprisingly related to the composition of intestinal flora and the presence of specific intestinal bacteria. In mouse and nematode models, intestinal flora also plays a key role in regulating the efficacy of chemotherapy drugs [1]. At the same time, intestinal flora also plays an important role in the aging process. The effects of its metabolites on mitochondrial dynamics, inflammatory response and nutrient absorption may be the mechanism by which intestinal flora helps human body fight or promote aging [2]. In neuroscience research, people even found that Alzheimer's disease, depression and other traditional brain diseases are closely related to intestinal flora [3]. In addition, the important role of intestinal flora in pneumonia, flatulence, constipation, irritable bowel syndrome, necrotizing enterocolitis, diabetes and other diseases has been gradually reported more and more [4].
At the beginning of 2018, three major international academic journals recommended human microbiome related studies on their covers
Similarly, in the prevention and control of chronic diseases and health management, the scientific community has previously been mainly concerned with medical genetics. Now, however, it seems that while single-gene diseases in humans are indeed linked to genes passed on from parents to children, a host of chronic diseases, including obesity and tertiary problems, are more or less rooted in "gut microbiota genetics". The way the mother chooses to give birth, the way the child is fed after birth, and what the family eats and drinks at each meal can affect the type, quantity and quality of the gut flora of everyone in the family over the long term. In other words, we need to fully consider the significant impact of microbial disruption on obesity, constipation, and a host of chronic diseases caused by acquired lifestyle and eating habits. Therefore, the detailed study of intestinal microorganisms will systematically provide important theoretical basis for obesity, digestive system diseases, diabetes and other metabolic diseases, immune system diseases, inflammatory reactions, and ultimately achieve the purpose of prevention and monitoring.
Gut microbiota is known to be involved in many metabolic processes in the body, but among the trillions of bacteria, what exactly plays what role and affects which metabolic pathways is not well understood. The reason for this limitation is that it is very difficult to directly observe microbiota interactions in humans, and microbiota interactions with the human body. On the one hand, intestinal flora is not only large and diverse, but most of them have not been cultured by humans. On the other hand, the quantitative detection of a large number of metabolites which reflect the changes of human metabolism is also a technical problem.
In recent years, with the development of multiple disciplines such as genomics and metabolomics, a new way to solve this problem has been provided. Through the combination of clinical medical samples, basic research and multi-omics techniques, a new research system for the analysis of intestinal flora composition and metabolic function can more accurately depict the blueprint of the interaction between flora and host metabolism. Similarly, the practical application in food science and animal science can more fully understand how different intestinal flora affect the body's metabolic process. Conversely, molecular markers of gut flora structure can be used to diagnose the degree of normal or deviant metabolism, and then target these specific gut bacteria to develop new ways to treat diseases by altering their interactions with the host.
Since reform and opening up, the achievements of health reform and development have been remarkable, and the health level of the people has been improved continuously. At the same time, China is also facing new challenges from industrialization, urbanization, population aging and the changing spectrum of diseases, ecological environment and lifestyle. We need to coordinate and solve the major and long-term issues concerning people's health. Understanding and applying targeted microbiome approaches, especially the popularization of scientific and effective nutrition concepts and lifestyles, will play an important role in advancing the goals of the Healthy China 2030 Outline. The National Nutrition Plan 2017-2030 specially formulated on the basis of the outline also clearly points out that we should develop the food nutrition and health industry, devote ourselves to balanced meal preparation, and vigorously develop the traditional "food and nutrition" service, that is, through balanced nutrition intake, complete intestinal function activity, improve the body's immunity, and enhance the national physical quality.
It can be said that human microbiome research is gradually moving from the laboratory to the market. The application of the most cutting-edge genomics scientific research achievements in the fields of disease diagnosis, health management and precision medicine is undoubtedly a great power to promote the transformation of scientific and technological achievements. With the further improvement of market demand and the improvement and support of functional institutional policies, intestinal research is unlocking secrets at a rapid pace, and the human microbiome industry, as The Times require, is opening up a new road of industrial innovation.
Member of Executive Committee of China Intestinal Congress
China Intestinal Conference is a large-scale interdisciplinary and cross-professional academic exchange platform jointly initiated and founded by Professor Zhang Invention of the Second Affiliated Hospital of Nanjing Medical University and Mr. LAN Canhui of Warm-hearted Biotechnology Research Institute. In 2018, The conference specially invited Air Force Military Medical University digestive disease hospital Professor Nie Yongzhan, Chinese Academy of Sciences Microbiology Institute Professor Zhu Baoli, Army Military Medical University Basic Medical school Professor Wei Hong, Chinese Academy of Sciences Beijing Institute of Life Sciences Professor Zhao Fangqing, Chinese Academy of Sciences Microbiology Institute Professor Wang Jun, "Protein & Co-organized by Dr. Zhang Xiaoxue of Cell Magazine.
The main activities of the conference include: China integrated Enterology academic conference (China flora transplantation conference), China human microbiome conference, China animal gut conference, Protein & Cell academic issue, Journal of Microbiology exchange, "Intestinal • Dao" speech, etc. Academician Fan Daiming, Academician Gao Fu, Academician Yin Yulong, Academician Wei Fuwen, Dusko Ehrlich, John Baines and other famous experts from home and abroad will give nearly 100 academic presentations at the conference.
This conference aims to bring together life science experts and medical experts from home and abroad who have made outstanding contributions in the field of intestinal tract, and conduct extensive exchanges and cooperation on topics such as intestinal microecosystem construction, intestinal flora homeostasis regulation, intestinal disease diagnosis and treatment, and intestinal interaction with other diseases. The organizers of the conference are committed to holding the most popular academic event with "gut" as the core theme in China and the world.
